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肥胖已成为了全球性的健康问题，病态性肥胖是多种疾病的危险因素。利用神经调控方法来治疗肥胖因为具有安全有效和低侵入性优势，获得了越来越多的关注。穴位针灸治疗、胃电刺激、小肠电刺激和迷走神经电刺激均在动物实验和（或）临床试验中获得了明确的治疗效果。针灸可能是通过影响下丘脑相关神经递质的释放来改变摄食调节以达到减少进食；迷走神经电刺激可能改变迷走神经对于消化道营养物质信息的传递而影响摄食中枢调节；而胃电刺激和小肠电刺激均被证明能直接改变胃肠动力降低营养物质吸收率，从而达到降低体质量的目的。“,”Obesity is becoming one of the most common health problems in the world and morbid obesity is the independent risk factor for various diseases.In recent years,neuromodulation has received increasing attention to treat obesity due to the advantages of safety,high effectiveness and less invasiveness.Acupunc-ture,gastric electrical stimulation, intestinal electrical stimulation and vagus nerve stimulation have been proved to be effective for weight reduction in animal trials and/or clinical studies.The mechanisms may be:acupuncture may alter the level of neurotransmitters released by hypothalamus ,while vagus nerve stimulation may change the information transited to the ventromedial nucleus of the hypothalamus;gastric electrical stim-ulation and intestinal electrical stimulation are proved to be able to alter gastrointestinal motility and reduce the nutrients absorption rate,so as to achieve the purpose of reducing the body mass.