目的建立自动固相萃取高效液相色谱法分析饮用水中8种酚类物质。方法 250 ml水样经全自动固相萃取仪用HLB固相萃取柱富集,高效液相TC-C18色谱柱以1%醋酸、甲醇和乙腈为流动相梯度分离,二极管阵列检测器275 nm~320 nm选择波长检测。结果用4通道固相萃取仪以10 ml/min上250 ml水样品,HLB固相萃取柱富集饮用水中低浓度8种酚类物质,乙腈洗脱;线性范围为3.98μg/L~1 243.75μg/L;相关系数均≥0.999 4;8种酚类物质的加标回收率为81.0%~100.9%,RSD为1.8%~3.9%;检出限为0.73μg/L~6.90μg/L。结论方法自动化程度高、耗时短,灵敏度高,重现性好,适用于饮用水中低浓度8种酚类化合物检测。 OBJECTIVE To establish an automatic solid phase extraction high performance liquid chromatographic method for the analysis of eight phenols in drinking water. Methods The 250 ml water samples were separated by HLB solid-phase extraction (SPE) column with an automatic solid-phase extraction (SPE) column. The mobile phases were separated on a TC-C18 column with a mobile phase of 1% acetic acid, methanol and acetonitrile. 320 nm selective wavelength detection. Results A 4-channel solid-phase extraction was performed on a 250 ml water sample at 10 ml / min. HLB solid-phase extraction (SPE) column was used to enrich eight kinds of low concentration phenols in drinking water and elute with acetonitrile. The linear range was 3.98 μg / L ~ 243.75 μg / L respectively; the correlation coefficients were all ≥0.999 4; the recoveries of the eight phenolic compounds were 81.0% -100.9% and the RSDs were 1.8% -3.9%; the detection limits were 0.73μg / L ~ 6.90μg / L . Conclusion The method has the advantages of high degree of automation, short time-consuming, high sensitivity and good reproducibility. It is suitable for the detection of 8 kinds of low-concentration phenols in drinking water.