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目的用免疫组织化学的方法，染色肾癌组织中的微血管，探讨血管形成（血管密度）与临床分期的关系。方法用第八因子相关抗原（FS－relatedantigen）的单克隆抗体，对41例肾细胞癌石蜡切片行免疫组化染色，分别计数×200视野和格子内染色的微血管数。结果Robson分期为Ⅰ期的血管数平均为421，Ⅱ期为56．3，Ⅲ-Ⅳ期为84．4。血管计数与临床分期相关（P＜0．05）。结论随着肿瘤恶性程度的增加，血管密度也增加，血管形成可作为判断肾细胞进展、估计预后的可靠指标。
Objective To investigate the relationship between the vascular formation (vascular density) and clinical stage by staining the microvessels in renal cell carcinoma with immunohistochemistry. Methods 41 cases of renal cell carcinoma paraffin sections were immunohistochemically stained with monoclonal antibody against Factor-relatedantigen (FS-relatedantigen), and the number of microvessels in × 200 visual field and the cells were counted. Results The average number of blood vessels in Robson stage Ⅰ was 421, in stage Ⅱ 56.3 and in stage Ⅲ-Ⅳ 84.4. Vascular count was correlated with clinical stage (P <0.05). Conclusion With the increase of malignant degree of the tumor, the blood vessel density also increases. The angiogenesis can be used as a reliable index to judge the progress of renal cell and estimate the prognosis.