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目的探讨HPV16/18型病毒检测与宫颈癌的相关性。方法选取宝鸡市中心医院2011-2014年收治的宫颈鳞癌患者100例作为宫颈癌组,并选取同期在该院体检中心接受体检的健康受试者100例作为对照组,分别取两组受试者的宫颈分泌物,提取DNA,通过q PCR技术对HPV16/18 DNA的载量进行测定,比较两组受试者的检测阳性率。结果宫颈癌患者和健康受试者的HPV16/18 DNA载量相对值分别为(7.77±4.05)和(4.50±3.05),阳性率分别为77.00%和27.00%,宫颈癌患者显著高于健康受试者,经比较差异有统计学意义(P<0.05)。结论宫颈鳞癌与HPV16/18型病毒感染之间存在显著相关性,通过早发现、早期疗,做好对高危人群的筛查是宫颈癌防治的重要方法。
Objective To investigate the relationship between HPV16 / 18 and cervical cancer. Methods 100 patients with cervical squamous cell carcinoma who were treated in Baoji Central Hospital from 2011 to 2014 were selected as cervical cancer group and 100 healthy subjects who received physical examination during the same period in the physical examination center of the hospital were selected as control group. Of cervical secretions, DNA extraction, qPCR HPV16 / 18 DNA load was measured, the test positive rate of the two groups were compared. Results The relative HPV16 / 18 DNA loads of cervical cancer patients and healthy subjects were (7.77 ± 4.05) and (4.50 ± 3.05) respectively, the positive rates were 77.00% and 27.00% respectively. The cervical cancer patients were significantly higher than those of healthy subjects The test subjects, the difference was statistically significant (P <0.05). Conclusions There is a significant correlation between cervical squamous cell carcinoma and HPV16 / 18 infection. Early screening and early treatment are the important ways to prevent and treat cervical cancer.