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为了探讨肺癌患者血清和尿中假尿苷浓度检测的临床意义，采用高效液相色谱法测定了４１例肺癌、１５例肺内良性占位性病变、２０例肺部感染患者及５０例健康献血员血清和尿中假尿苷的浓度。肺癌患者血清、尿中假尿苷浓度分别显著高于肺内良性占位性病变、肺部感染患者和健康对照者（Ｐ均＜０．００１）。广泛型小细胞性肺癌患者的假尿苷浓度高于局限型患者，非小细胞性肺癌Ⅲ、Ⅳ期患者高于Ⅰ、Ⅱ期患者。结果提示血清和尿中假尿苷浓度的检测对肺癌的诊断及病情判断有重要价值。
To explore the clinical significance of serum and urinary pseudouridine concentrations in lung cancer patients, 41 cases of lung cancer, 15 cases of benign lung lesions, 20 cases of pulmonary infection, and 50 cases of healthy blood donation were determined by HPLC. Serum and urine concentrations of pseudouridine. The serum and urinary concentrations of pseudouridine in lung cancer patients were significantly higher than those in benign space-occupying lesions, lung infections, and healthy controls, respectively (P < 0.001 for all). The uridine concentration in patients with extensive small cell lung cancer was higher than that in patients with localized type, and patients with stage III and IV non-small cell lung cancer were higher than patients with stage I and II. The results suggest that the detection of serum and urine concentrations of pseudouridine has important value in the diagnosis of lung cancer and judgment of disease.