随着耐药结核病,尤其是耐多药结核病(MDR-TB)和广泛耐药结核病(XDR-TB)发病率的不断上升使得结核病疫情再度上升,成为全球所必须共同面对的重大公共卫生和社会问题。进入21世纪,随着人类回归自然、追求天然潮流的发展,在天然产物中寻找抗结核新药已成为当前抗结核新药研发的热点领域之一。现就近年来天然产物或基于天然产物半合成或全合成的抗耐多药结核优秀候选药物进行综述。 With the rising incidence of drug-resistant TB, especially MDR-TB and XDR-TB, the tuberculosis epidemic has risen again and become a major public health and Social Issues. Entering into the 21st century, with the return of mankind to the nature and the pursuit of the development of the natural trend, searching for new anti-TB drugs in natural products has become one of the hot spots in the research and development of new anti-TB drugs. In recent years, the review summarizes natural products or excellent candidates for semi-synthetic or fully synthetic multi-drug resistant tuberculosis based on natural products.