缺血性脑血管病损伤过程极为复杂,其发病机制涉及脑组织能量代谢紊乱、兴奋性氨基酸毒性、细胞内钙超载、自由基损伤、神经细胞凋亡、炎症反应等多个环节。在脑梗死神经元损伤中氧化应激和内质网应激可同时或相继发生,钙是两 The process of ischemic cerebrovascular disease is extremely complicated. Its pathogenesis involves many aspects such as energy metabolism disturbance of brain tissue, toxicity of excitatory amino acids, overload of intracellular calcium, free radical damage, apoptosis of nerve cells and inflammatory reaction. Oxidative stress and endoplasmic reticulum stress can occur simultaneously or sequentially in cerebral infarction neuronal damage, with calcium being two