儿童难治性肾病，目前尚无特效治疗措施，６巯基嘌呤是治疗难治性肾病综合征的有效药物之一。现将我科近几年观察的结果报告如下。１　对象与方法１．１　研究对象　２８例难治性肾病患儿，为我科１９９４年７月～１９９８年１０月住院的患儿，男性１９例，女性９例，平均年 Children refractory nephropathy, there is no specific treatment, 6-mercaptopurine is one of the effective drugs for the treatment of refractory nephrotic syndrome. The results of our recent observations in recent years are reported below. 1 Subjects and Methods 1.1 The study of 28 children with refractory renal disease, our department July 1994 ~ October 1998 hospitalized children, 19 males and 9 females, the average annual