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目的检测氧化还原因子1(Ref-1)在胃癌中的表达及意义。方法收集120例胃癌和15例正常胃黏膜组织,用免疫组织化学法检测Ref-1基因的表达,并分析Ref-1与胃癌临床病理因素间的关系。结果 Ref-1在胃癌和正常胃黏膜组织中呈胞核、胞质或核质共表达。Ref-1胞质表达与胃癌分化程度相关(p<0.05)。结论 Ref-1表达在胃癌的发生发展中发挥重要作用。
Objective To detect the expression of redox factor 1 (Ref-1) in gastric cancer and its significance. Methods 120 cases of gastric cancer and 15 cases of normal gastric mucosa were collected. The expression of Ref-1 gene was detected by immunohistochemistry and the relationship between Ref-1 and clinicopathological parameters of gastric cancer was analyzed. Results Ref-1 was co-expressed in nucleus, cytoplasm and nucleus in gastric cancer and normal gastric mucosa. The expression of Ref-1 in cytoplasm correlated with the degree of gastric cancer differentiation (p <0.05). Conclusion Ref-1 expression plays an important role in the development of gastric cancer.