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肥大细胞在过敏和变态反应以及固有免疫和获得性免疫中发挥重大作用。越来越多的证据也表明肥大细胞与炎症性疾病有关。在没有过敏反应典型的脱颗粒情况下，肥大细胞可以通过选择性释放的促炎性介质在不同的生理过程中发挥不同的作用。了解肥大细胞介质的选择性释放有助于解释肥大细胞在许多不同的生理过程中如何发挥正向和负向的双重功能。另外，揭示肥大细胞选择性分泌也有助于研发具有新的治疗前景的肥大细胞抑制剂。“,”Mast cells play a major role in allergy and allergic reactions,as well as in innate immunity and acquired immune.Currently,a growing body of evidence also points to the relationship between mast cells and inflammatory disease.Without the typical allergic reaction-degranulation,mast cells have different effects on various physiological processes via selectively released proinflammatory mediators .Learning the selective release of mast cell medium can help explain how the mast cells in many different physiological processes can play the dual function of positive and negative impact.In addition, revealing the selective secretion of mast cells can also contribute to the research and development of new mast cell inhibitors .