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脂蛋白酯酶(lipoproteinlipase,LPL)是调节脂蛋白代谢的一种关键酶,如具有水解血浆脂蛋白中三酰甘油的作用等.体内LPL减少会导致血三酰甘油升高和高密度脂蛋白胆固醇降低,增加患动脉粥样硬化的危险.通过提高LPL的活性可以抑制动脉粥样硬化的发生发展.已有的研究说明NO 1886促进心肌和脂肪组织LPLmRNA表达,提高心肌、脂肪组织、骨骼肌和血液中LPL活性,因而改善脂蛋白代谢,抑制动脉粥样硬化.
Lipoprotein lipase (LPL) is a key enzyme in the regulation of lipoprotein metabolism, such as the role of triacylglycerol in the hydrolysis of plasma lipoproteins, etc. In vivo LPL reduction leads to elevated blood triglyceride and high density lipoprotein Reduce cholesterol and increase the risk of atherosclerosis.It can inhibit the development of atherosclerosis by increasing the activity of LPL.Previous studies have shown that NO 1886 can promote the expression of LPL mRNA in myocardium and adipose tissue and increase the expression of cardiac muscle, adipose tissue and skeletal muscle And LPL activity in the blood, thereby improving lipoprotein metabolism and inhibiting atherosclerosis.