论文部分内容阅读
目的探讨抑癌基因ｐ１６与喉癌的生物学行为的关系。方法采用免疫组织化学法检测３９例喉癌中ｐ１６基因表达情况。结果喉癌组织ｐ１６阳性表达率为６６．７％，ｐ１６蛋白阳性率在鳞癌Ⅰ、Ⅱ、Ⅲ级中分别为１００％、６４.７％。５０％，显示ｐ１６蛋白表达阳性率随喉癌的病理分级的上升而降低，ｐ１６阳性与阴性组之间的１～５年的生存率则无明显差异。结论抑癌基因ｐ１６的表达与肿瘤的类型有关，而喉癌预后好于其它肿瘤可能与ｐ１６的失表达少有关。
Objective To investigate the relationship between the tumor suppressor gene p16 and the biological behavior of laryngeal carcinoma. Methods The expression of p16 gene in 39 cases of laryngeal carcinoma was detected by immunohistochemistry. Results The positive rate of p16 in laryngeal carcinoma was 66.7%. The positive rate of p16 protein was 100% and 64.7% in grade Ⅰ, Ⅱ and Ⅲ of squamous cell carcinoma respectively. 50%, showing that the positive rate of p16 protein expression with the pathological grade of laryngeal cancer decreased, p16 positive and negative group between 1 to 5 years of survival was no significant difference. Conclusion The expression of tumor suppressor gene p16 is related to the type of tumor, whereas the prognosis of laryngeal carcinoma is better than that of other tumors.