目前,人们已确知衰老所带来的各种代谢变化有时与疾病的发生有关。在内分泌学领域中,随着大白鼠的衰老,对丘脑-下垂体-肾上腺系统负反馈的敏感性就会降低,结果导致皮质酮的基础分泌量增加。同时,这些大白鼠对各种应激反应的适应能力也有所降低。一般认为这是由于中枢神经系统的衰老,肾上腺糖皮质激素的受体变性或丧失的缘故。结果在应激状态下,衰老大白鼠的皮质酮就会分泌过多,这可能与各种疾病的发生有关。已知在应激条件下,各种肿瘤细胞的分裂速度加快,而免疫系统的排斥反应却降低。而且随 At present, it is well known that the metabolic changes brought about by aging are sometimes related to the occurrence of diseases. In the field of endocrinology, as rats age, their sensitivity to negative feedback to the thalamus-pituitary-adrenal system decreases, resulting in increased basal cortisone secretion. At the same time, these rats have a reduced ability to adapt to various stress responses. Generally believed that this is due to the aging of the central nervous system, adrenal glucocorticoid receptor denaturation or loss of sake. Results In stress state, corticosterone in aged rats will be overproduced, which may be related to the occurrence of various diseases. It is known that under stressful conditions, the speed of division of various tumor cells is accelerated while the rejection of the immune system is reduced. And with