目前认为GH分泌主要受GHRH和生长抑素控制,糖皮质激素对GH合成和释放的调节也起着重要作用,它能抑制人及实验动物的生长。用激素治疗可减弱GH对胰岛素引起的低血糖反应,并减少GH的产生率。因为给糖皮质激素不能耗竭垂体GH,所以这种低的反应提示下丘脑功能或垂体反应异常。然而,近来有人发现在大鼠中,地塞米松实际上竞然增加了垂体对GHRH的敏感性,提示精皮质激素在垂体引起的相反效应。本文作者研究了糖皮质激素对培养的垂体细胞GH分泌的双相作用。 Now that GH secretion is mainly controlled by GHRH and somatostatin, glucocorticoid also plays an important role in the regulation of GH synthesis and release, it can inhibit the growth of human and experimental animals. Hormone therapy can reduce GH on insulin-induced hypoglycemia, and reduce the incidence of GH. Because glucocorticoids can not deplete pituitary GH, this low response suggests abnormal hypothalamic or pituitary responses. However, it has recently been observed that dexamethasone actually raises the sensitivity of the pituitary to GHRH in rats, suggesting the opposite effect of ploidy in the pituitary gland. The authors studied the biphasic effects of glucocorticoids on the GH secretion of cultured pituitary cells.