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血液中高浓度前列腺素与许多消化道癌肿的远处转移有关。本文主要探讨了前列腺素 E_2(PGE_2)与结肠、直肠癌肝、肺转移的关系。通过对癌肿组织、癌肿局部静脉血,以及外周血中 PGE_2的浓度测定,结果表明:外周血PGE_2高浓度与肝、肺转移有密切关系,外周血中 PGE_2的显著升高有助于结肠、直肠癌远处转移的发现。研究对象为39名病人(结肠癌19例,直肠癌20例),包括肝转移7例,肺转移1例。另有结直肠癌术后复发性肺转移5例,共44铡。10例早期胃癌作为对照。测定应用的是 PGE_2~-(125)~IRIA 药盒。
High concentrations of prostaglandins in the blood are associated with distant metastasis of many digestive tract cancers. This article mainly discusses the relationship between prostaglandin E 2 (PGE 2) and colon, rectal cancer liver and lung metastasis. Through the determination of the concentration of PGE 2 in cancer tissues, local venous blood of cancerous tumors, and peripheral blood, the results showed that the high concentration of PGE 2 in peripheral blood was closely related to liver and lung metastasis, and the significant increase of PGE 2 in peripheral blood was helpful for the colon. The discovery of distant rectal cancer metastasis. The study subjects were 39 patients (19 colon cancer, 20 rectal cancer), including 7 liver metastases and 1 lung metastasis. Another case of colorectal cancer recurrence after lung metastasis in 5 cases, a total of 44 铡. Ten cases of early gastric cancer served as controls. The PGE_2~-(125)~IRIA kit was used for the assay.