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本文观察了800rad照射后胃肠肌电的变化及切斷内脏神经与电刺激迷走神经对官的影响,初步分析了电离辐射引起胃排空延迟的机理。结果是:800rad照后大鼠胃肠肌电的峰波平均振幅胃幽部窦部照后1小时至第4天明显降低(P<0.05);幽门括约肌政变不大;十二指肠球部照后第3～7天明显下降(P<0.01)。切断内脏神经后照射大鼠胃肠肌电的峰波平均振幅胃幽门窦部变化不大,幽门括约肌照后1小时至第5天明显升高(P<0.05),十二指肠球部照后第3～7天明显下降(P<0.05)。800rad照后第4天大鼠胃对电刺激迷走神经的反应性明显降低(P<0.01)。上述结果表明:照后胃排空延迟的原因不仅与神经-体液调节紊乱有关,而且与射线损伤了平滑肌,使其兴奋性暂时的功能性降低有关。此外照后由于十二指肠球部运动的变化而使内感受器对胃运动的调节发生紊乱也是值得重视的因素。
In this paper, the changes of gastrointestinal EMG after 800 rad irradiation and the effects of cutting off visceral nerve and electrical stimulation of vagus nerve on the organ were observed. The mechanism of delayed gastric emptying induced by ionizing radiation was analyzed. The results showed that the mean peak amplitude of gastrointestinal myoelectricity after 800 rad irradiation was significantly decreased from 1 hour to 4 days (P <0.05); the pyloric sphincter did not change much; the duodenal bulb After 3 to 7 days significantly decreased (P <0.01). The average peak-wave amplitude of gastrointestinal myoelectrical irradiation in rats after cutting off the visceral nerve did not change much in the pyloric sinus. The pyloric sphincter was significantly increased from 1 hour to 5 days after irradiation (P <0.05) After 3 to 7 days decreased significantly (P <0.05). On the 4th day after 800 rad irradiation, the reactivity of the stomach to electrical stimulation of the vagus nerve was significantly decreased (P <0.01). The above results show that the delayed gastric emptying is not only related to neuro-humoral dysregulation, but also related to the temporary impairment of the excitability of the smooth muscle by radiation. In addition, as a result of changes in the duodenal bulb movement after the endocervical receptors regulate gastric motility disorder is also worthy of attention.