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目的:探讨孕晚期乙型肝炎免疫球蛋白(HB IG)对阻断乙肝病毒(HBV)母婴垂直传播的临床效果。方法:对杭州市拱墅区近郊农村乙肝病毒携带家庭高发人群进行乙肝病毒母婴垂直传播情况调研。阻断组:18例HBsAg(+)孕晚期(7、8、9月)乙型肝炎免疫球蛋白(HB IG)400 IU/月肌注。非阻断组:20例HBsAg(+)孕妇自然孕产。生后两组婴儿均按正规乙肝疫苗接种。1岁后做肝功、乙肝抗体检测、对比调研。结果:阻断组:阻断乙肝病毒垂直传播成功率83.9%,失败率16.1%。非阻断组:阻断乙肝病毒垂直传播成功率42.9%,失败率51.8%。阻断组与非阻断组间比较有统计学意义(P<0.01)。结论:乙肝病毒携带者孕晚期乙型肝炎免疫球蛋白阻断乙肝病毒母婴垂直传播有显著疗效。
Objective: To investigate the clinical effect of hepatitis B immunoglobulin (HB IG) in the third trimester of pregnancy on blocking the vertical transmission of hepatitis B virus (HBV) in maternal and infant. Methods: To investigate the vertical transmission of hepatitis B virus (HBV) in infants from rural areas with high incidence of hepatitis B virus infection in suburban Gongshu District, Hangzhou City. Blocking group: 18 cases of HBsAg (+) third trimester (7, 8, 9 months) hepatitis B immunoglobulin (HB IG) 400 IU / month intramuscular injection. Non-blocking group: 20 cases of HBsAg (+) pregnant women naturally pregnant. After birth, both infants were vaccinated according to the regular hepatitis B vaccine. 1 year old after liver function, hepatitis B antibody testing, comparative research. Results: In the blocking group, the success rate of blocking vertical transmission of hepatitis B virus was 83.9% and the failure rate was 16.1%. Non-blocking group: blocking the success rate of vertical transmission of hepatitis B virus 42.9%, the failure rate of 51.8%. There was a significant difference between blocking group and non-blocking group (P <0.01). Conclusion: Hepatitis B virus carriers in the third trimester of hepatitis B immunoglobulin block hepatitis B virus vertical transmission of mother and child have a significant effect.