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目的分析小儿下呼吸道感染病原菌分布特征并探讨合理用药方法。方法指定具有专业知识及丰富经验的临床实验室人员完成100例下呼吸道感染患儿病原菌及耐药性检验工作，根据患儿病原菌分布情况及耐药性特征提出合理用药指导。将所得数据经专业软件完成统计学检验。结果100例痰液标本中共分离获得100株致病菌，其中以肺炎克雷伯菌、大肠埃希菌、铜绿假单胞菌所占比例较高，分别为33.00%、25.00%、16.00%(<0.05)；对下呼吸道感染患儿主要致病菌耐药性分析可知，小儿下呼吸道感染主要致病菌对亚胺培南、庆大霉素、头孢哌酮等药物耐药性较高(<0.05)结论临床医生应准确掌握小儿下呼吸道感染相关特征，给予各项检查明确病原菌及耐药性，根据患儿实际情况制定正确有效的治疗方案，保障患儿生活质量及生命安全。“,”Objective To analyze the distribution characterist-ics of pathogenic bacteria in lower respiratory tract infections in children and to explore the rational use of drugs.Methods The specified with professional knowledge and rich experience in the clinical laboratory personnel to complete the 100 patients with lower respiratory tract infection in children and drug resistance of pathogenic bacteria in inspection work according to with pathogenic bacteria distribution and drug resistance characteristics is proposed to guide rational drug use.The data obtained by the professional software to complete statistical test.Results 100 cases of sputum,CPC separation obtained 100 strains of pathogenic bacteria,the pneumonia gram Reber fungus,Escherichia coli,Pseudomonas aeruginosa bacteria accounted for a higher proportion,respectively 33.00% and 25.00%,16.00%( <0.05);on the lower respiratory tract infection in children with drug resistance of the main pathogenic bacteria analysis shows that,in children with lower respiratory tract infection mainly caused by bacteria to imipenem and gentamicin,cefoperazone drug resistance was higher ( <0.05).Conclusion Clinicians should accurately grasp the characteristics in children with lower respiratory tract infection,give the check to clear the pathogens and drug resistance,according to the actual situation of children develop correct and ef ective treatment,the patients'quality of life and life safety guarantee.