肿瘤细胞内核酸库的代谢与正常细胞有显著不同 ,不同类型肿瘤细胞内核酸库代谢也有明显差异 ,而且核酸库的改变还与肿瘤的恶性程度及治疗前景有着密切的关系。本文拟就近年来的有关文献 ,对几种肿瘤细胞内核酸库的特点及其代谢进行了对比 ,讨论了细胞内核酸库的测定方法 ,以期用于新型抗肿瘤药物及其作用机制的研究 ,并为临床诊断及预后提供一定的判断依据。 The metabolism of the nucleic acid pool in tumor cells is significantly different from that of normal cells. There are also significant differences in the metabolism of nucleic acid pools in different types of tumor cells, and changes in the nucleic acid pool are also closely related to the degree of malignancy and treatment prospects of tumors. This article intends to compare the characteristics and metabolism of several nucleic acid pools in several tumor cells in recent years, and discusses methods for the determination of intracellular nucleic acid pools in order to study novel antitumor drugs and their mechanisms of action. Provide a basis for the judgment of clinical diagnosis and prognosis.