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人们常说,对肾移植受者免疫抑制剂的调整是一门艺术,足见其复杂和高深,而免疫抑制方案中争论最多是糖皮质激素的保留或撤除。糖皮质激素为肾移植的成功立下了汗马功劳,半个世纪以来,它已经成为最经典、使用最广泛的免疫抑制剂,至今仍然在肾移植中发挥着无可替代的作用。同样,由于激素众所周知的不良反应,人们总是设法尽量减少甚至撤除激素的使用。激素撤除方案一直是肾移植领域讨论的热点话题,目前国际上已有大量关于激素撤除方案的临床对照研
It is often said that the adjustment of immunosuppressants in kidney transplant recipients is an art that shows its complexity and sophistication, whereas the most controversial issue in immunosuppressive regimens is the retention or withdrawal of glucocorticoids. Glucocorticoids have made a significant contribution to the success of kidney transplantation. For half a century, glucocorticoid has become the most classical and widely used immunosuppressant and still plays an irreplaceable role in renal transplantation. Also, people are always trying to minimize or even eliminate the use of hormones due to the hormonal known adverse reactions. Hormone withdrawal program has been a hot topic in the field of kidney transplantation, there are a large number of international studies on hormone withdrawal program