晚期糖基化终产物受体(RAGE)是一种细胞跨膜型蛋白受体,可以与多种配体相互作用形成配体—RAGE轴,激活细胞内多条信号通路,从而通过增强氧化应激反应、改变细胞功能等引起疾病的发生。早期发现于代谢性疾病如糖尿病中,可以与糖代谢终极产物(AGEs)相结合影响疾病的发生发展。RAGE与糖尿病、动脉粥样硬化等血管性疾病、中枢及外周神经性疾病、免疫性疾病等证实有着紧密关系,并且是体内重要信号通 The receptor for advanced glycation end-products (RAGE) is a cell-transmembrane protein receptor that interacts with ligands to form the ligand-RAGE axis that activates multiple intracellular signaling pathways, thereby enhancing oxidative stress Shock response, change cell function caused by the disease. Early detection of metabolic diseases such as diabetes, can be combined with the final glucose metabolism products (AGEs) affect the development of the disease. RAGE and diabetes, atherosclerosis and other vascular diseases, central and peripheral neurological diseases, immune disease confirmed that there is a close relationship, and is an important signal in vivo