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目的探讨血压水平对2型糖尿病肾病(DN)24h尿蛋白排泄量(UPE)的影响。方法测定21例经降压治疗并严格控制血糖水平的DN患者在治疗前后的UPE,按治疗后血压的达标程度分成达标组(A组)和未达标组(B组)。结果与治疗前相比,两组治疗后血压和UPE均有不同程度的下降,A组的下降有统计学意义(P<0.05)。与B组比较,A组在治疗后UPE下降有统计学意义(P<0.05)。结论高血压和高血糖对DN的UPE有影响,在血糖控制的同时,严格控制血压对DN的治疗很重要。
Objective To investigate the effect of blood pressure on urinary protein excretion (UPE) of type 2 diabetic nephropathy (DN). Methods UPE in 21 DN patients undergoing antihypertensive treatment and controlling blood glucose level strictly before and after treatment were divided into standard group (A) and non-standard group (B) according to the standard of blood pressure after treatment. Results Compared with before treatment, blood pressure and UPE decreased in both groups after treatment, and the decrease in group A was statistically significant (P <0.05). Compared with group B, UPE decreased after treatment in group A (P <0.05). Conclusion Hypertension and hyperglycemia have effects on the UPE of DN. It is very important to control the blood pressure strictly on the treatment of DN while controlling blood glucose.