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高效抗逆转录病毒治疗(HAART)能有效地抑制人类免疫缺陷病毒(HIV)复制,大大降低获得性免疫缺陷综合征(艾滋病,AIDS)的患病率和病死率,却无法彻底清除病毒,进而发展为慢性病毒感染性疾病。慢性HIV感染破坏宿主免疫系统导致肠屏障破坏、肠黏膜功能紊乱及菌群易位加快疾病进程。而重建肠道微生态平衡和改善肠黏膜功能对重建宿主免疫系统至关重要。以下综述近年来关于艾滋病相关肠屏障损伤及其靶向治疗的研究进展,为进一步研究和改进艾滋病治疗措施、降低HIV感染患病率和病死率提供参考。
Highly active antiretroviral therapy (HAART) effectively inhibits human immunodeficiency virus (HIV) replication and greatly reduces the prevalence and mortality of acquired immunodeficiency syndrome (AIDS) but does not completely eliminate the virus The development of chronic viral infectious diseases. Chronic HIV infection damages the immune system of the host leading to damage of the intestinal barrier, dysfunction of the intestinal mucosa and translocation of the bacteria to speed up the progression of the disease. Reconstruction of the gut microflora and improvement of intestinal mucosal function are crucial for the reconstruction of the host immune system. The following summarizes recent research progress on AIDS-related intestinal barrier injury and its targeted therapy for further study and improvement of AIDS treatment measures to reduce the prevalence of HIV infection and mortality provide a reference.