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目的:通过建立规范的、实时在线的儿童严重脓毒症数据库并初步应用，实现对严重脓毒症儿童的信息化管理，为科研及临床提供数据支持的同时，为参加数据库的多家单位，搭建同质化的科研及临床工作平台。方法:设计、研发、建立儿童严重脓毒症在线数据库系统，山东省儿童脓毒症诊治协作组的19家成员单位共同实时填报，初步分析数据库中已录入的患儿基本信息、治疗及预后等情况。结果:(1)初步建立的实时在线儿童严重脓毒症临床数据库，对严重脓毒症患儿的信息进行分类储存、逻辑检索、统计分析及绘表制图。(2)2015年1月至2020年12月共住院治疗602例严重脓毒症患儿，其中男341例(56.6%)，女261例(43.4%)，年龄中位数16个月，<1岁230例(38.2%)，1~5岁274例(45.5%)，6岁及以上98例(16.3%)。343例(57.0%)患儿来自农村地区。181例患儿(30.1%)被发现有基础疾病。最常见的原发感染部位是呼吸系统(246例，40.8%)，275例(45.7%)患儿合并脓毒性休克。严重脓毒症儿童的院内病死率为15.6%。多因素Logistic回归分析提示，入院24 h儿童死亡风险评分Ⅲ高，合并急性呼吸窘迫综合征、急性肾损伤，接受机械通气和血管活性药物治疗为严重脓毒症儿童院内死亡的独立危险因素(n P<0.05)。n 结论:儿童严重脓毒症数据库能够为儿童脓毒症的科研及临床工作提供数据支持，辅助临床决策的制定及改进，同时也搭建了同质化的科研及临床工作平台，利于参与单位的共同规范发展。“,”Objective:Through the establishment and preliminary application of standardized, real-time and online database of severe sepsis in children, we can realize the information about management of children with severe sepsis, providing data to support scientific research and clinical work, and building a homogeneous scientific research and clinical platform for multiple units participating in constructing the database.Methods:We designed, developed and established an online database system for children with severe sepsis, which was filled in in real time by 19 member units of Diagnosis and Treatment Collaboration Group for Sepsis in Children in Shandong Province.The basic information, treatment and prognosis of children entered in the database were preliminarily analyzed.Results:(1)A real-time online disease-specific database for severe sepsis in children was established primarily, with the classification, storage, logical retrieval, statistical analysis and map-making of the information of children with severe sepsis.(2)Further analysis was conducted on the clinical data of 602 children with severe sepsis, which had been recorded in the database.There were 341 males(56.6%)and 261 females(43.4%). The median age was 16 months.There were 230(38.2%)children younger than 1 year old, and 274 children aged from 1 to 5 years old(45.5%), 98 children(16.3%)were 6 years old and above.Three hundred and forty-three cases(57.0%)were from rural areas.One hundred and eighty-one cases(30.1%)were found to have basic diseases.The primary site of infection was the respiratory system(40.8%). The in-hospital mortality was 15.6% in children with severe sepsis.Multivariate Logistic regression analysis showed that high pediatric risk of mortality score Ⅲ score at 24 hours after admission, acute respiratory distress syndrome, acute renal injury, mechanical ventilation and vasoactive drug treatment were independent risk factors for in-hospital death in children with severe sepsis(n P<0.05).n Conclusion:The disease-specific database of severe sepsis in children can provide data for scientific research and clinical practice of sepsis management in children, and contribute to the formulation and improvement of clinical decision-making in the future.Simultaneously, it has also constructed a homogeneous scientific research and clinical work platform, which may contribute to the common development of the participatory units.