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目的探讨脑出血与一氧化氮、抗氧化剂的关系及其临床意义。方法检测９８例脑出血患者和１００例健康对照者的血浆一氧化氮（Ｐ－ＮＯ）、维生素Ｃ（Ｐ－ＶＣ）、维生素Ｅ（Ｐ－ＶＥ）、β－胡萝卜素（Ｐ－β－ＣＡＲ）含量，采用直线回归和相关、逐步回归等分析患者病情（临床神经功能缺损程度积分，ＮＤＳ）以及颅内血肿量与上述指标的关系。结果与对照组比较，观察组的Ｐ－ＮＯ平均值显著升高（Ｐ＜０．０１），Ｐ－ＶＣ、Ｐ－ＶＥ、Ｐ－β－ＣＡＲ平均值均显著降低（Ｐ＜０．０１）；逐步回归分析发现，患者ＮＤＳ与Ｐ－ＮＯ、Ｐ－ＶＣ值相关最为密切，颅内血肿量与Ｐ－ＮＯ、Ｐ－ＶＥ值相关最为密切。结论脑出血患者体内ＮＯ代谢反应异常，氧化、抗氧化平衡严重失调
Objective To explore the relationship between cerebral hemorrhage and nitric oxide and antioxidants and its clinical significance. Methods The levels of plasma nitric oxide (P-NO), vitamin C (P-VC), vitamin E (P-VE) and β-carotene (P-β-CAR) were determined in 98 patients with cerebral hemorrhage and 100 healthy controls. ) Content, using linear regression and correlation, stepwise regression analysis of the patient’s condition (clinical neurological deficit score, NDS) and intracranial hematoma volume and the above indicators. Results Compared with the control group, the mean P-NO in the observation group was significantly increased (P <0.01) and the average values of P-VC, P-VE and P-β-CAR were significantly decreased ; Stepwise regression analysis found that patients with NDS and P-NO, P-VC was most closely related to the amount of intracranial hematoma and P-NO, P-VE values most closely. Conclusion The metabolism of NO in patients with intracerebral hemorrhage is abnormal, with a serious imbalance of oxidation and antioxidation