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圣路易斯大学药理和生理科学Thomas Burris博士等揭示了能调控“生物钟蛋白”活性的小分子,提供了潜在调控昼夜节奏和治疗与它有关的功能障碍如睡眠和焦虑症问题。研究结果发表在Nature Communications杂志上。Burris等研究靶向一个名为REV-ERB蛋白的化合物,REV-ERB蛋白似乎在调节哺乳动物的内部生物钟中发挥关键作用。研究表明给予小鼠能开启REV-ERB的合成化合物,改变了小鼠的昼夜节律。该小组检查靶向REV-ERB药物对睡眠和清醒模式的作用,发现该化合物会增加觉醒状态,降低REM和慢波睡眠,特别是降低忧虑。
Pharmacological and Physiological Sciences, St. Louis University Dr. Thomas Burris et al. Revealed small molecules that can modulate the activity of “biological clock proteins”, providing potentially circadian rhythms and treating the dysfunctions associated with it such as sleep and anxiety disorders. The findings are published in Nature Communications. The Burris et al. Study targeted a compound called the REV-ERB protein that appears to play a key role in regulating the mammalian internal clock. Studies have shown that giving mice a synthetic compound that turns on REV-ERB alters the circadian rhythm of mice. The team examined the effects of drugs targeting REV-ERB on sleep and wakefulness patterns and found that the compound increased wakefulness, decreased REM and slow-wave sleep, and in particular decreased anxiety.