1960年Nowell及Hungerford首先报告了在美国费城(Philadelphia)发现慢性粒细胞性白血病(简称慢粒)患者的丝状分裂中期细胞内G组有一长臂缺失的染色体,认为系标记染色体,特称之Ph＇染色体,以后国内外的研究相继证实。此一发现对慢粒的诊断、分型、预后及发病机理的探讨,均有着重要意义。本院从1978年正式开展染色体的实验工作,现将两年中所见的3例慢粒急变的临床及染色体变化报告于下: 材料与方法病例:3例均为住院病人,临床症状、体征、血象及骨髓象检查均符合慢粒 1960 Nowell and Hungerford first reported in the United States Philadelphia (Philadelphia) found that patients with chronic myeloid leukemia (mitochondria) mitotic metaphase G cells have a long arm missing chromosomes, that Department of chromosomes, specifically called Ph ’chromosome, after the study at home and abroad have confirmed. This discovery of CML diagnosis, classification, prognosis and pathogenesis, are of great significance. The hospital from 1978 formally carried out the experimental work of chromosomes, now see the two years, three cases of chronic pelvic inflammatory disease clinical and chromosomal changes reported in the next: Materials and Methods: 3 cases were hospitalized patients, clinical symptoms and signs , Blood and bone marrow examination are in line with CML