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由人类获得性免疫缺陷病毒(HIV)感染引起的病理学改变是复杂、多方面的,其中感染过程中导致免疫激活和疾病进展的一个关键因素是微生物易位,在胃肠道表现较早,并出现相应的临床症状。人类和动物感染SIV后,导致细菌易位形成的主要因素包括胃肠黏膜上皮屏障破坏和持续性免疫激活。以下就HIV感染期间持续性免疫激活与肠道微生物易位的关系进行综述。
Pathological changes caused by human acquired immunodeficiency virus (HIV) infection are complicated and multifaceted. One of the key factors that lead to immune activation and disease progression during infection is microbial translocation, which manifests earlier in the gastrointestinal tract, And the corresponding clinical symptoms. The main factors leading to the formation of bacterial translocations after infection of human and animal SIV include the destruction of the gastrointestinal mucosal epithelium and the sustained immune activation. The following is a review of the relationship between persistent immune activation and gut microbial translocations during HIV infection.