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目的应用Meta分析方法评价甘露糖结合凝集素2(MBL 2)基因P 52位点多态性与结核病易感性的关系。方法计算机检索中英文数据库Pub Med、中国期刊全文数据库、中国生物医学文献数据库、维普数据库、万方数据库等,查找各数据库从建库至2015年5月20日公开发表的关于研究MBL 2基因多态性与结核病易感性关系的相关文献。由2名评价者根据纳入与排除标准筛选文献,提取并评价文献资料后,采用Rev Man 5.2软件及Stata 10.0软件进行Meta分析。结果最终共纳入9个病例对照研究,其中包括结核病组1 282例,对照组1 483例,经异质性检验,各研究间存在统计学异质性(P<0.10),故总体分析采用随机效应模型。Meta分析结果显示:显性模型(DD+AD vs.AA)中,对于总体人群而言,MBL 2基因P 52位点与结核病易感性关联无统计学意义[OR=1.46,95%CI(0.87,2.43),P=0.15];但根据种族进行亚组分析时,在亚洲人群中,MBL 2基因P 52位点与结核病易感性关联有统计学意义[OR=1.96,95%CI(1.27,3.03),P=0.003],在高加索人群中,MBL 2基因P 52位点与结核病易感性关联无统计学意义[OR=1.36,95%CI(0.52,3.56),P=0.53]。结论在亚洲人群中,MBL 2基因P 52位点可能是增加结核病患病风险的危险因素,在高加索人群中,MBL 2基因P 52位点多态性与结核病的发病风险可能不存在相关性。
Objective To evaluate the relationship between P 52 polymorphism of mannose binding lectin 2 (MBL 2) gene and susceptibility to tuberculosis using Meta analysis. Methods The databases of Pub Med, Chinese Journal Full-text Database, Chinese Biomedical Literature Database, VIP Database and Wanfang Database were searched by computer. The database of MBL 2 gene was searched and published publicly on May 20, 2015 Status and tuberculosis susceptibility related literature. Two reviewers screened the literature based on the inclusion and exclusion criteria, extracted and evaluated the literature data, and then performed the meta-analysis using Rev Man 5.2 software and Stata 10.0 software. Results A total of 9 case-control studies were included, including 1 282 TB cases and 1 483 control subjects. There was statistical heterogeneity among the studies (P <0.10) by heterogeneity test, so the overall analysis was randomized Effect model. Meta-analysis showed that there was no significant correlation between the P 52 locus of MBL 2 gene and the susceptibility to tuberculosis in the dominant population (DD + AD vs. AA) [OR = 1.46, 95% CI (0.87 , 2.43), P = 0.15]. However, in Asian subgroup analysis, P 52 locus of MBL 2 gene was associated with susceptibility to tuberculosis (OR = 1.96, 95% CI 1.27, 3.03), P = 0.003]. There was no significant correlation between P 52 locus of MBL 2 gene and susceptibility to tuberculosis in the Caucasians (OR = 1.36, 95% CI 0.52, 3.56, P = 0.53). Conclusions P 52 locus of MBL 2 gene may be a risk factor for increasing the prevalence of tuberculosis in Asian population. There may be no correlation between P 52 locus polymorphism of MBL 2 gene and the risk of tuberculosis in Caucasians.