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目的探讨急性脑梗死患者血浆同型半胱氨酸(Hcy)水平与血清C反应蛋白(CRP)、白介素-6(IL-6)水平的关系。方法选择2014年10月-2015年10月诊断为急性脑梗死患者120例,入院后酶法检测Hcy,酶联免疫吸附法检测IL-6,免疫散射比浊法测定血清CRP水平,用Pearson相关分析血浆Hcy与IL-6、CRP水平间相关性。以血浆Hcy≥10μmol/L为基准,将患者分为高同型半胱氨酸血症组(高值组)54例与正常同型半胱氨酸血症组(正常组)66例。比较2组患者血清IL-6、CRP水平,采用美国国立卫生研究院卒中量表(NIHSS)评价2组患者神经功能缺损程度。结果高值组血清IL-6、CRP水平及NIHSS评分均高于正常组,差异均有统计学意义(P<0.05)。Pearson相关分析显示血浆Hcy与IL-6、CRP水平成直线相关(r1=0.471,r2=0.517,P<0.05)。结论急性脑梗死患者血浆Hcy水平与机体炎性反应水平关系密切,机体炎性反应越明显,患者神经功能缺损程度越严重。
Objective To investigate the relationship between plasma homocysteine (Hcy) levels and serum C-reactive protein (CRP), interleukin-6 (IL-6) levels in patients with acute cerebral infarction. Methods 120 patients were diagnosed as acute cerebral infarction from October 2014 to October 2015. Hcy was detected by enzyme-linked immunosorbent assay (ELISA) and IL-6 by enzyme-linked immunosorbent assay (ELISA). Serum CRP levels were measured by immune nephelometry. Pearson correlation Analysis of plasma Hcy and IL-6, CRP levels between the correlation. Patients were divided into high homocysteine group (high value group) 54 cases and normal homocysteine group (normal group) 66 cases based on plasma Hcy≥10μmol / L. The serum levels of IL-6 and CRP were compared between the two groups. The degree of neurological deficit in the two groups was evaluated using the National Institutes of Health Stroke Scale (NIHSS). Results Serum levels of IL-6, CRP and NIHSS in high value group were significantly higher than those in normal group (P <0.05). Pearson correlation analysis showed that plasma Hcy had a linear correlation with IL-6 and CRP levels (r1 = 0.471, r2 = 0.517, P <0.05). Conclusion The plasma Hcy level in patients with acute cerebral infarction is closely related to the level of inflammatory reaction in the body. The more obvious the inflammatory reaction is, the more severe the neurological deficits are.