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病毒唑(virazole,三氮唑核苷ribavirin)是一种新合成的抗病毒药。近年来,大量实验和临床研究证实该药具有广谱抗RNA和DNA病毒的作用,且具有不易产生耐药性、活性强、副作用少等特点。目前临床上用于一些病毒性疾病特别是一些传染病的治疗,取得了较好效果。作用机制病毒唑的作用机制主要是抑制病毒合成酶,它进入细胞后磷酸化为三氮唑核苷单磷酸,与肌苷、鸟苷相似竞争性地抑制肌苷-5′-单磷酸脱氢酶,使肌苷单磷酸不能转化
Ribavirin (virazole) is a newly synthesized antiviral drug. In recent years, a large number of experiments and clinical studies have confirmed that the drug has a broad spectrum of anti-RNA and DNA viruses, and has not easy to produce resistance, activity, less side effects and so on. At present, the clinical treatment of some viral diseases, especially some infectious diseases, has achieved good results. Mechanism of Action Ribavirin mechanism of action is mainly the inhibition of viral synthetase, it enters the cell after phosphorylation of ribavirin monophosphate, and inosine, guanosine competitively inhibited inosine-5’-monophosphate dehydrogenation Enzymes, inosine monophosphate can not be transformed