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目的 探讨尿α1-微球蛋白 (α1-MG)、尿 β2 -微球蛋白 ( β2 -MG)和尿微量白蛋白 (uAlb)的检测对评价系统性红斑狼疮 (SLE)患者早期肾损害的意义。方法 采用RIA法分别测定了SLE患者的尿α1-MG、尿β2 -MG和uAlb ,并与健康人做对照。结果 SLE患者的尿α1-MG、尿 β2 -MG和uAlb测定结果分别为 ( 4 7 80± 5 4 30 )mg/L、( 339 70± 2 35 0 0 ) μg/L和 ( 6 4 30± 75 5 0 ) μg·mL-1,分别与健康对照组比较 ,均有显著性差异(P <0 0 1) ,SLE组比健康对照组显著升高。SLE患者中尿常规异常组的尿α1-MG、尿 β2 -MG和uAlb的测定结果为 ( 4 6 30± 5 5 4 0 )mg/L、( 4 97 90± 2 2 5 4 0 )ug/L和 ( 99 90± 71 70 ) μg·mL-1,分别与尿常规正常组比较 ,尿α1-MG在两组间无明显差异 (P >0 0 5 ) ,而尿 β2 -MG和uAlb均有显著差异 (P <0 0 1) ,尿常规异常组明显高于尿常规正常组。结论 尿α1-MG、尿 β2 -MG和uAlb的测定能够反映SLE患者早期肾损害 ,且对于评价肾脏受损程度有一定意义
Objective To investigate the significance of urinary α1-microglobulin (α1-MG), urinary β2-microglobulin (β2-MG) and urinary microalbumin (uAlb) in the assessment of early renal damage in patients with systemic lupus erythematosus . Methods Urine α1-MG, urinary β2-MG and uAlb were measured by RIA in patients with SLE and compared with healthy controls. Results The urinary α1-MG, urinary β2-MG and uAlb in SLE patients were (4780 ± 5430) mg / L, (33970 ± 2350) μg / L and 75 5 0) μg · mL-1, respectively, compared with the healthy control group, there was significant difference (P <0.01), SLE group was significantly higher than the healthy control group. Urinary α1-MG, urinary β2-MG and uAlb in the urine abnormal group were significantly higher than those in the SLE group (4 6 30 ± 5 5 4 0) mg / L, (4 97 90 ± 2 2 5 4 0) L and (99 90 ± 71 70) μg · mL-1, respectively, urinary α1-MG had no significant difference between the two groups (P> 0.05), while urinary β2-MG and uAlb There was a significant difference (P <0.01), urinary abnormalities were significantly higher than the urine normal group. Conclusion The determination of urinary α1-MG, urinary β2-MG and uAlb can reflect the early renal damage in patients with SLE, and has some significance for evaluating the extent of renal damage