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目的:探讨砷对小鼠肝肾脂质过氧化的影响及维生素 E的拮抗作用。 方法 :采用亚慢性毒性实验方法 ,实验结束后分别测定小鼠肝肾组织中脂质过氧化产物丙二醛 (MDA)含量及超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GSH- Px)的活力 ,同时观察维生素 E(Vit E)干预后对染砷小鼠体内抗氧化水平的影响。结果 :随着砷染毒剂量的增加 ,小鼠肝肾组织中 MDA含量显著增加 ,SOD、GSH- Px活性显著降低 ,且呈剂量 -效应关系。Vit E能显著抑制 MDA生成量 ,提高 SOD、GSH- Px活性。结论:砷可致机体脂质过氧化 ,Vit E可拮抗其脂质过氧化作用
Objective: To investigate the effects of arsenic on lipid peroxidation in liver and kidney of mice and the antagonism of vitamin E. Methods: The sub-chronic toxicity test was adopted. After the experiment, the content of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and to observe the effect of vitamin E intervention on the anti-oxidation of arsenic-exposed mice. Results: With the increase of arsenic dose, the content of MDA and the activities of SOD and GSH-Px in liver and kidney were significantly increased, and the dose-effect relationship was observed. Vit E could significantly inhibit the production of MDA and increase the activity of SOD and GSH-Px. Conclusion: Arsenic can cause lipid peroxidation in the body, Vit E can antagonize its lipid peroxidation