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本文综述了有机磷农药乙酰甲胺磷体内、体外潜性遗传毒作用的有关研究。体外试验:用鼠伤寒沙门氏菌TA 100、TA98,TA1537和小鼠L5178 YTK~(+/-)淋巴瘤细胞进行的致突变试验结果表明乙酰甲胺磷对鼠伤寒沙门氏菌TA 100在无代谢活化时呈弱阳性,对TA 98和TA 1537在有或无代谢活化时均呈阴性,L 5178 YTK~(+/-)淋巴瘤细胞在加或不加S_9代谢活化时均呈弱阳性。乙酰甲胺磷与强致突变剂亚硝基胍、迭氮化钠、甲磺酸乙酯、二甲苯蒽比较,其强度要弱100～1000倍。体内试验:小鼠姐妹染色单体交换试验,小鼠骨髓细胞染色体畸变试验,小鼠微核试验,小鼠显性致死试验在乙酰甲胺磷为最大耐
This review summarizes the genetic toxicity of organophosphorus pesticides acephate in vivo and in vitro. In Vitro Assays: Mutagenicity tests with Salmonella typhimurium TA 100, TA98, TA1537 and mouse L5178 YTK +/- (+/-) lymphoma cells showed that acephate was not metabolically active against Salmonella typhimurium TA 100 Weakly positive, both TA 98 and TA 1537 were negative with or without metabolic activation, and L 5178 YTK +/- cells were weakly positive with or without S 9 metabolic activation. Acephate and mutagenic agents nitrosoguanidine, sodium azide, ethyl methanesulfonate, xylene anthracene, its intensity is weak 100 to 1000 times. In vivo tests: mouse sister chromatid exchange test, mouse bone marrow cell chromosome aberration test, mouse micronucleus test, mouse dominant lethal test in the acephate maximum resistance