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目的:观察转移因子口服液对老年反复呼吸道感染患者体液免疫功能的影响及疗效。方法:老年反复呼吸道感染患者74例随机分为观察组与对照组。两组患者急性发作期均予抗感染及对症治疗,观察组患者在此基础上加用转移因子口服液10 ml,po,tid,连用3个月。比较两组患者治疗前后血清免疫球蛋白IgG、IgA和IgM水平的变化、临床疗效及药品不良反应。结果:观察组患者血清IgG、IgA和IgM水平较治疗前明显上升(P<0.05),而对照组治疗前后血清IgG、IgA和IgM水平无明显变化(P>0.05);观察组总有效率显著高于对照组(P<0.01),两组患者药品不良反应比较,差异无统计学意义(P>0.05)。结论:转移因子口服液辅助治疗反复呼吸道感染具有较好的临床疗效及安全性,与其提高血清免疫球蛋白IgG、IgA和IgM水平,增强机体的体液免疫功能密切相关。
Objective: To observe the effect of transfer factor oral liquid on humoral immunity in elderly patients with recurrent respiratory tract infection and its efficacy. Methods: 74 elderly patients with recurrent respiratory tract infection were randomly divided into observation group and control group. Two groups of patients with acute attack were anti-infective and symptomatic treatment, patients in the observation group on the basis of the use of transfer factor oral solution 10 ml, po, tid, once every 3 months. The changes of serum immunoglobulin IgG, IgA and IgM levels before and after treatment were compared between the two groups. The clinical efficacy and adverse drug reactions were compared. Results: Serum IgG, IgA and IgM levels in the observation group were significantly higher than those before treatment (P <0.05), while serum IgG, IgA and IgM levels in the control group had no significant changes before and after treatment (P> 0.05). The total effective rate in the observation group was significantly Higher than the control group (P <0.01), two groups of patients with adverse drug reactions, the difference was not statistically significant (P> 0.05). Conclusion: The transfusion factor oral liquid adjuvant treatment of recurrent respiratory tract infection has good clinical efficacy and safety, and it is closely related to the increase of serum immunoglobulin IgG, IgA and IgM levels and enhance the body’s humoral immune function.