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β_2-微球蛋白(β_2-microglobulin简称β_ 2-m)是瑞典Bergg?rd等于1968年首先从伴有肾小管损伤的Wilsont’s病及慢性镉中毒患者尿中分离纯化的.由于它的分子量小,并且蛋白电泳的位置位于球蛋白β_2区带,故得名.它在生物学、免疫学和临床医学中的作用日益受到重视,特别是在用β_2-m来反映各种肾脏疾患时肾功能状态方面应用较为广泛.但是近年来,人们研究更多的是β_2-m的免疫学特性、和HLA抗原的关系,在某些自身免疫性疾病中的变化以及在某些特殊免疫反应中的意义.本文就近年
β_2-microglobulin (β_2-microglobulin referred to as β_ 2-m) is the Swedish Bergg? rd equal to the first in 1968 with renal tubular injury Wilsont’s disease and chronic cadmium poisoning in patients with urine isolated and purified due to its small molecular weight, And the location of protein electrophoresis is located in the domain of globulin β_2, hence its name.Its role in biology, immunology and clinical medicine has received increasing attention, especially in the use of β_2-m to reflect various renal disorders renal function status However, in recent years, more attention has been paid to the immunological characteristics of β_2-m, the relationship with HLA antigens, the changes in some autoimmune diseases, and the significance in some special immune responses. This article in recent years