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目的:探讨白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子(TNF-α)对早产胎膜早破孕妇患绒毛膜羊膜炎的监测价值。方法:对68例早产胎膜早破孕妇血中IL-6、IL-8和TNF-α进行检测,并以正常孕妇30例作为对照组。结果:36例绒毛膜羊膜炎患者血清IL-6、IL-8均明显高于非绒毛膜羊膜炎者和对照组,差异有统计学意义(P<0.01);绒毛膜羊膜炎患者血清TNF-α水平也升高,但无统计学意义(P>0.05);绒毛膜羊膜炎患者血IL-8、TNF-α水平与IL-6含量呈正相关。结论:孕妇血中IL-6和IL-8联合测定,可作为监测绒毛膜羊膜炎的重要指标;血TNF-α的测定有一定的辅助作用。
Objective: To investigate the value of interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) in the monitoring of chorioamnionitis in pregnant women with premature rupture of membranes. Methods: The blood levels of IL-6, IL-8 and TNF-α in 68 preterm premature rupture of membranes were measured. The normal pregnant women were used as the control group. Results: The serum levels of IL-6 and IL-8 in 36 chorioamnionitis patients were significantly higher than those in non-chorioamnionitis and control groups (P <0.01). The levels of serum TNF- α, but there was no statistical significance (P> 0.05). The levels of IL-6 and IL-6 in serum of patients with chorioamnionitis were positively correlated. Conclusion: The combined determination of IL-6 and IL-8 in blood of pregnant women can be used as an important indicator to monitor chorioamnionitis. The determination of blood TNF-α has some auxiliary effects.