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应用酶免疫技术择118例慢性肝炎、肝硬变患者进行血清转化生长因子β_1(Transforming growth factor β_1,TGFβ_1)含量的测定,并将其与Ⅲ型胶原(Ⅲ-c)、肝功能指标相关性分析。结果显示,患者血清TGFβ_1水平随慢迁肝→慢活肝→肝硬变组逐渐递增,均高于正常对照组(P<0.05),血清TGFβ_1与Ⅲ-c、谷丙转氨酶呈显著性正相关,与白/球比值,血清总胆红素不相关。提示血清TGFβ_1能够反映慢性肝病肝纤维化的形成,它与Ⅲ-c的联合检测对早期诊断肝纤维化有重要意义。
Enzyme immunoassay was used to determine the level of TGF-β1 in 118 patients with chronic hepatitis and cirrhosis, and the correlation between TGF-β1 and type Ⅲ collagen (Ⅲ-c), liver function analysis. The results showed that serum TGFβ_1 levels gradually increased with chronic liver metastasis and chronic liver cirrhosis group (all P <0.05), and serum TGFβ_1 was positively correlated with Ⅲ-c and alanine aminotransferase , And white / ball ratio, serum total bilirubin irrelevant. It is suggested that serum TGFβ_1 can reflect the formation of hepatic fibrosis in chronic liver disease. The combination of it with Ⅲ-c is of great significance for the early diagnosis of hepatic fibrosis.