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目的探讨血清生长激素释放肽(ghrelin)水平与代谢综合征(MS)的关系。方法在东北大学教职工中随机抽取78例MS和49名非MS教职工进行人体测量、血清ghrelin及MS指标测定。结果病例组教职工血清ghrelin为(0.74±0.77)ng/mL,低于对照组的(1.98±2.70)ng/mL,差异有统计学意义(t=4.52,P<0.01);Q1、Q2、Q3、Q4组教职工MS检出率分别为87.0%(20/23)、72.2%(26/36)、56.3%(18/32)和38.9%(14/36),4组教职工MS检出率差异有统计学意义(χ2=16.18,P<0.01);Logistic回归分析结果表明,Q2组和Q1组发生MS的危险度分别是Q4组的3.67和8.86倍;多元线性回归分析结果表明,性别、体质指数、腰围身高比和低密度脂蛋白胆固醇是预测血清ghrelin水平的变量(R2=0.46,F=20.05,P<0.01)。结论血清ghrelin水平降低可增大MS患病的危险度。
Objective To investigate the relationship between serum ghrelin level and metabolic syndrome (MS). Methods A total of 78 MS and 49 non-MS faculty members were randomly selected from Northeastern University faculty for human measurement, serum ghrelin and MS index. Results The serum ghrelin of the teaching staff was (0.74 ± 0.77) ng / mL in the case group, which was significantly lower than that of the control group (1.98 ± 2.70) ng / mL (t = 4.52, P <0.01) The detection rates of MS in Q3 and Q4 were 87.0% (20/23), 72.2% (26/36), 56.3% (18/32) and 38.9% (14/36), respectively (Χ2 = 16.18, P <0.01). Logistic regression analysis showed that the risk of MS in Q2 group and Q1 group were 3.67 and 8.86 times respectively in Q4 group. The results of multivariate linear regression analysis showed that, Sex, body mass index, waist circumference ratio and low density lipoprotein cholesterol were predictors of serum ghrelin levels (R2 = 0.46, F = 20.05, P <0.01). Conclusion The decrease of serum ghrelin may increase the risk of MS.