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目的探讨卵巢上皮性癌患者血清人附睾上皮分泌蛋白4(HE4)水平的改变及与临床分期的关系。方法选取因盆腔肿物在我院住院拟行手术治疗的患者,其中卵巢上皮性癌54例(A组),盆腔良性疾病60例(B组);健康女性30例作为对照(C组)。其中A组:国际妇产科联盟分期中晚期(Ⅲ、Ⅳ期)29例,早期(Ⅰ、Ⅱ期)25例;高分化17例,中低分化37例;淋巴结转移48例,无淋巴结转移6例。用ELISA法检测三组人群血清HE4水平,分析HE4水平与临床分期的关系。结果 A、B、C组血清HE4水平分别为(563.65±414.78)pmol/L、(70.46±107.08)pmol/L、(47.53±23.35)pmol/L,A组血清HE4水平高于B、C组(P<0.01)。A组临床中晚期、中低分化及有淋巴结转移患者HE4水平高于早期、高分化及无淋巴结转移患者(P<0.01)。结论 HE4在卵巢上皮性癌中高表达,其表达水平与卵巢癌临床分期、肿瘤细胞学分化及淋巴结转移有关。
Objective To investigate the changes of serum human epididymal epithelium secreting protein 4 (HE4) level in patients with epithelial ovarian cancer and its relationship with clinical stage. Methods A total of 54 cases of ovarian epithelial carcinoma (group A) and 60 cases of pelvic benign disease (group B) were selected because of pelvic masses hospitalized in our hospital. 30 healthy women served as control group (group C). In group A, there were 29 cases of stage Ⅲ and Ⅳ in the International Union of Gynecology and Obstetrics, 25 cases of early stages Ⅰ and Ⅱ, 17 cases of well-differentiated, 37 cases of moderate-poorly differentiated, and 48 cases of lymph node metastasis without lymph node metastasis 6 cases. The levels of serum HE4 in three groups were detected by ELISA, and the relationship between HE4 level and clinical stage was analyzed. Results The serum levels of HE4 in groups A, B and C were (563.65 ± 414.78) pmol / L, (70.46 ± 107.08) pmol / L and (47.53 ± 23.35) pmol / (P <0.01). The level of HE4 in patients with advanced stage, moderately poorly differentiated and lymph node metastasis in group A was higher than that in early stage, well differentiated and without lymph node metastasis (P <0.01). Conclusion HE4 is overexpressed in epithelial ovarian cancer, and its expression level is related to the clinical stage, tumor cell differentiation and lymph node metastasis.