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PTEN/MMAC1/TEP1基因是Steck等 3个研究小组在 1997年克隆到的一个新基因 ,具有酪氨酸磷酸酶的核心基序 ,并与张力蛋白、辅助蛋白高度同源 ,是目前发现的第一个具有磷酸酶活性的抑癌基因。本文介绍了其抑癌作用的几条不同途径及在人体多种肿瘤组织中的突变和丢失情况。
The PTEN / MMAC1 / TEP1 gene is a new gene cloned by three research groups such as Steck in 1997. It has the core motif of tyrosine phosphatase and is highly homologous to the tensility protein and accessory protein. It is the first A tumor suppressor gene with phosphatase activity. This article describes several different ways of its tumor suppressor and mutation and loss in a variety of human tumor tissues.