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目的探索血管紧张素原(AGT)T235M基因多态性与皮层下动脉硬化性脑病(BD)的关系。方法应用聚合酶链式反应-限制性片段长度多态性(PCR-PFLP)技术检测BD患者(BD组)62例、单纯原发性高血压病(EH)患者(EH组)57例、正常健康查体者(正常对照组)71例的AGTT235M基因型,研究其与BD的关系。结果①BD组较EH组有更高的MM+MT基因型分布频率(χ2=7.02,P<0.01),且BD组M等位基因分布频率明显高于EH组(χ2=6.33,P<0.05);②BD组与正常对照组间MM+MT基因型(χ2=0.32,P>0.05)及M等位基因(χ2=0.86,P>0.05)分布差异均无统计学意义;③与EH组比较,正常对照组有更低的TT基因型(χ2=10.61,P<0.01)及T等位基因(χ2=11.91,P<0.01)分布频率。结论 AGTT235M基因MM或MT基因型与BD相关,AGTT235M基因TT基因型及T等位基因与EH相关,而AGTT235M基因型表现为MT或MM型的EH患者可能更易患BD。
Objective To explore the relationship between angiotensinogen (AGT) T235M gene polymorphism and subcortical arteriosclerotic encephalopathy (BD). Methods Sixty-two patients with BD (BD), 57 patients with simple essential hypertension (EH) (EH) were detected by PCR-PFLP. Normal 71 cases of healthy volunteers (normal control group) AGTT235M genotype to study its relationship with BD. Results ① The distribution frequency of MM + MT genotype in BD group was higher than that in EH group (χ2 = 7.02, P <0.01), and the distribution frequency of M allele in BD group was significantly higher than that in EH group (χ2 = 6.33, P <0.05) ; ② The distribution of MM + MT genotype (χ2 = 0.32, P> 0.05) and M allele (χ2 = 0.86, P> 0.05) between the BD group and the normal control group had no statistical significance; ③Compared with the EH group, The normal control group had lower frequencies of TT genotypes (χ2 = 10.61, P <0.01) and T allele (χ2 = 11.91, P <0.01). Conclusion The genotypes of MM or MT of AGTT235M gene are associated with BD. The TT genotype and T allele of AGTT235M gene are associated with EH, whereas those with AGTT235M genotype of MT or MM may be more susceptible to BD.