S-100蛋白为神经系统特异性蛋白,由Moore于1965年首次从牛脑中分离而得。它既可在周围神经系统的雪旺氏细胞内检出亦存在于神经胶质母细胞瘤、星形细胞瘤、室管膜瘤及雪旺氏瘤等神经组织肿瘤中。有人还借助于火箭免疫电泳研究了雪旺氏瘤的恶性度与S-100蛋白含量间的相互关系。 The S-100 protein is a nervous system-specific protein that was first isolated from bovine brain by Moore in 1965. It can be detected both in Schwann cells of the peripheral nervous system and in nerve tissue tumors such as glioblastoma, astrocytoma, ependymoma, and Schwann’s tumor. Some people also used rocket immunoelectrophoresis to study the relationship between the degree of malignancy of Schwann’s tumor and the content of S-100 protein.