对年青人胃癌未能作出早期诊断和未分化癌发病率增长,是治疗成功的主要障碍。本文复习了Texas大学Anderson医院和肿瘤研究所近30年来诊治35岁以下胃癌患者的经验,其目的是确定年青人胃癌的临床病理特征及早期认识本病的诊断准则。材料:1946～1976年间,35岁以下的胃癌患者共37例,占同期收治1,383例胃癌的2.7％。临床资料:37例中,30～35岁为23例,30岁以下14例;年龄最轻23岁。全组男女比例为1:13,30岁以下的男女比例为1:2.5,而同期706例50岁以上者为2:1。1/4患者有家属癌肿史。常见症状包括上腹痛、体重减轻、呕吐及早饱。呕血、黑粪、虚弱及吞咽困难少见。症状出现到首次就诊的平均时间为2.4月。症状出现到确诊为胃癌的平均时间为6.8月。体格检查多数无特殊发现,但30％患者有上腹部压痛。37例中10例触及肿块,其中5例在上腹部,2例在直肠窝,2例为盆腔肿块,1例为锁骨上淋巴结肿大;2例在初诊时已有腹水。实验室检查的价值不大。23％的患者有贫血;20例曾作肝功能检查,7例示异常,其中以碱性磷酸酶升高最常见;5例作粪便隐血检查,4例阳性;3例作胃液分析,均无 The failure to make early diagnosis of gastric cancer in young people and the increase in the incidence of undifferentiated cancer is a major obstacle to treatment success. This article reviews the experience of the Anderson Hospital and Cancer Institute of Texas University in the past 30 years in the diagnosis and treatment of gastric cancer patients under 35 years of age. Its purpose is to determine the clinicopathological characteristics of young people with gastric cancer and early diagnosis of the disease diagnosis criteria. Materials: From 1946 to 1976, 37 cases of gastric cancer patients under the age of 35 were in total, accounting for 2.7% of 1,383 cases of gastric cancer treated during the same period. Clinical data: Of the 37 cases, 23 were 30 to 35 years old and 14 were younger than 30; the youngest were 23 years old. The proportion of males and females in the whole group was 1:13. The ratio of males and females below 30 years of age was 1:2.5, while the proportion of 706 patients over the age of 50 was 2:1 in the same period. One quarter of the patients had a family history of cancer. Common symptoms include epigastric pain, weight loss, vomiting, and early satiety. Hematemesis, dark feces, weakness, and difficulty swallowing are rare. The average time from the onset of symptoms to the first visit was 2.4 months. The average time from the onset of symptoms to the diagnosis of gastric cancer was 6.8 months. Most of the physical examinations were not specifically found, but 30% had upper abdominal tenderness. Of the 37 patients, 10 had palpable masses, of which 5 were in the upper abdomen, 2 in the rectal fossa, 2 in the pelvic mass, 1 in the supraclavicular lymph node enlargement, and 2 had ascites at the time of initial diagnosis. Laboratory inspections are of little value. 23% of patients had anemia; 20 had liver function tests, 7 showed abnormalities, among which alkaline phosphatase increased most commonly; 5 cases had fecal occult blood tests, 4 cases were positive; 3 cases had gastric fluid analysis, none