为探讨ｂｃｌ２、ｃｍｙｃ 基因蛋白在胃原发癌与转移癌中的表达特点，应用ＳＰ免疫组织化学方法，对８０ 例胃癌、３５ 例相应淋巴结转移癌细胞进行ｂｃｌ２ 、ｃｍｙｃ 基因蛋白的检测，并对２ 种基因的生物学和临床病理意义进行研究和探讨。结果发现ｂｃｌ２ 、ｃｍｙｃ 基因蛋白的阳性表达率在３５ 例胃原发癌中分别为３１．４ ％ 、５７．１ ％ ，在淋巴结转移癌中分别为６８．６ ％ 、３１．４ ％ ，ｂｃｌ２ 在淋巴结转移癌中的表达率明显高于相应的原发癌（ Ｐ＜０ ．０１） ，而ｃｍｙｃ 阳性表达率明显低于相应的原发癌（Ｐ＜０ ．０５）。在８０ 例胃癌中，ｂｃｌ２、ｃｍｙｃ 的阳性表达率分别为４６ ．３％ 、６７．５％ ，其中分化较好者为６４ ．７％ 、７３．５％ ，分化较差者为３２．６ ％ 、６３ ．０％ ；肠型胃癌为６２．５％ 、７１．８％ ，弥漫型胃癌为３５ ．４％ 、６４ ．６％ ；无淋巴结转移的胃癌为６５ ．２ ％ 、６９ ．６ ％ ，有淋巴结转移者分别为３８．６％ 、６８．７％ 。结果提示：ｂｃｌ２、ｃｍｙｃ 基因蛋白的表达可能参与转移癌的形成；ｂｃｌ２、ｃｍｙｃ 基因蛋白的阳性表达与患者性别、年龄、肿瘤发生部位、浸润深度无关；胃 To investigate the expression characteristics of bcl2 and cmyc genes in primary gastric cancer and metastatic cancer, SP immunohistochemistry was used to perform bcl2 and c32 on 80 cases of gastric cancer and 35 cases of corresponding lymph node metastatic cancer cells. The detection of myc gene protein, and the biological and clinical pathological significance of the two genes were studied and discussed. The results showed that the positive expression rates of bcl2 and cmyc genes were 31.4 % and 57.1 % respectively in 35 cases of primary gastric cancers, and 68.6 % and 31.4 % respectively in lymph node metastases. The expression of bcl-2 in lymph node metastasis was significantly higher than that of the corresponding primary cancer (P<0.01), while the positive rate of c-myc was significantly lower than that of the corresponding primary cancer (P<0.05). ). In 80 cases of gastric cancer, the positive expression rates of bcl-2 and c-myc were 46. 3%, 67.5%, of which 64 were better differentiated. 7%, 73.5%, poorly differentiated 32.6 %, 63. 0%; intestinal type of gastric cancer was 62.5%, 71.8%, diffuse gastric cancer was 35. 4%, 64. 6%; no lymph node metastasis of gastric cancer was 65. 2%, 69. 6 % of patients with lymph node metastasis were 38.6% and 68.7%, respectively. The results suggest that the expression of bcl2 and cmyc genes may be involved in the formation of metastatic carcinoma; the positive expression of bcl2 and cmyc genes is not related to gender, age, site of tumor, and depth of invasion;