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目的 探讨元通胶囊治疗血管性痴呆 (VD)的疗效及机理。方法 采用反复结扎双侧颈总动脉 ,同时腹腔注射硝普钠的方法复制出缺血再灌注大鼠痴呆模型 (I R) ,分假手术组、模型组、西药对照组、中药治疗 (高、中、低剂量 )组。从 4个方面观察了元通胶囊对实验性大鼠I R模型的治疗作用。结果 元通胶囊可减轻缺血再灌注损伤 ,改善学习和记忆障碍 ,具有抗脂质过氧化反应的能力。且呈一定的量效关系 ,剂量越大疗效越显著。结论 证明元通胶囊具有显著的防治血管性痴呆 (VD)作用。
Objective To investigate the efficacy and mechanism of Yuantong capsule in the treatment of vascular dementia (VD). Methods Repetitive ligation of bilateral common carotid artery and intraperitoneal injection of sodium nitroprusside were performed to replicate the ischemia-reperfusion rat dementia model (IR), divided into sham operation group, model group, western medicine control group, and traditional Chinese medicine treatment (high and middle , low dose) group. The therapeutic effect of Yuantong capsule on experimental rat I R model was observed from four aspects. Results Yuantong Capsules can reduce ischemia-reperfusion injury, improve learning and memory impairment, and have the ability to resist lipid peroxidation. And there is a certain dose-effect relationship, the greater the dose, the more significant the effect. Conclusion It is proved that Yuantong capsule has a significant effect on preventing and treating vascular dementia (VD).