厚皮性骨膜病(Pachydermoperiostosis),系常染色体显性遗传、有家族倾向的综合征。我院收治2例,系亲兄弟,除具有该病典型特征外,还伴有胃溃疡和糖尿病,在文献中更属少见。报告如下,并略加讨论。例1 男,26岁,主因胃溃疡术后9年,多饮、多尿5年,手足粗大3年,于1983年12月24日入 Pachydermoperiostosis, Department of autosomal dominant inheritance, familial tendency of the syndrome. 2 cases admitted to our hospital, Department of the pro-brothers, in addition to the typical features of the disease, but also associated with gastric ulcer and diabetes, is even more rare in the literature. The report is below and discussed briefly. Example 1 male, 26 years old, mainly due to gastric ulcer after 9 years, polydipsia, polyuria for 5 years, 3 weeks of hand and foot coarse, on December 24, 1983 into