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目的 :探讨呕必亭预防高剂量顺铂腹腔热灌注所致恶心呕吐。方法 :57例患者接受DDP100mg/m2 +43℃生理盐水2500～3000ml腹腔灌注 ,腹灌第1周期用呕必亭或用对照药物胃复安 +地塞米松或恩丹西酮 ,第2周期交换应用。结果 :预防急性呕吐的有效率 ,呕必亭为88.9 % ,恩丹西酮为85.7% ,胃复安 +地塞米松为66.7 %(P<0.025)。其中完全缓解率为63.9 %、61.9 %、38.9 %(P<0.05) ,对慢性呕吐的预防(2～5天)的有效率分别为 :72.2 %～91.9 %、61.9%～90.4%、27.8 %～69.4 %(P<0.05)。结论 :呕必亭能有效地预防高剂量顺铂腹腔热灌注所致的呕吐 ,与恩丹西酮相仿 ,明显优于胃复安 +地塞米松 ,且给药方便。
Objective: To investigate the effect of vomiting on the prevention of nausea and vomiting induced by intraperitoneal hyperthermic perfusion of high dose cisplatin. Methods: 57 patients received intraperitoneal instillation of 2500 ~ 3000ml DDP100mg / m2 + 43 ℃ saline, the first cycle of abdominal irrigation with vomiting pavilion or with the control drug metocloptin + dexamethasone or ondansetron, the second cycle of exchange application. Results: The effective rate of prevention of acute vomiting was 88.9% for vomiting, 85.7% for ondansetron and 66.7% for dexamethasone and metoclopramide (P <0.025). The complete remission rate was 63.9%, 61.9%, 38.9% (P <0.05), and the effective rates of prevention (2-5 days) of chronic vomiting were 72.2% -91.9%, 61.9% -90.4%, 27.8% ~ 69.4% (P <0.05). Conclusion: Etafitine can effectively prevent vomiting induced by intraperitoneal hyperthermic perfusion of high dose cisplatin, which is similar to ondansetron, and is superior to metoclopramide and dexamethasone conveniently.