多中心网状组织细胞增生症又名类脂质——皮肤——关节炎,是一种以皮肤、粘膜发生结节与丘疹性损害,伴破坏性关节炎为特征的罕见疾病。1990年我国姚氏等首先报告2例,此后15年来,有关该病的报告极少。现将我们所见到的1例报告如下。患者女,54岁。因皮肤泛发性结节、关节肿痛2年,就诊前1月出现不规则发热,关节痛加剧,手活动受限并行走困难,遂就诊我院内科,因疑为“麻风病”而转我科诊治。体检:体温37.8℃,血压 Multi-center Reticulocyte Hyperplasia, also known as Lipid-Skin-Arthritis, is a rare disease characterized by nodular and papular lesions of the skin and mucous membranes, with destructive arthritis. In 1990, China’s Yao et al first reported 2 cases and the following 15 years reported very few reports about the disease. Now we see a report of the following. Female patient, 54 years old. Due to skin panniculous nodules, joint swelling and pain 2 years, 1 month before treatment irregular fever, increased joint pain, hand movement is limited and difficult to walk, then visit our hospital internal medicine, because of suspected “leprosy” And go to our department diagnosis and treatment. Physical examination: body temperature 37.8 ℃, blood pressure