论文部分内容阅读
目的观察微创碎吸术手术时机对高血压脑出血患者血清白介素(IL-6)、肿瘤坏死因子-α(TNF-α)水平及生活质量的影响。方法将220例高血压脑出血患者随机分为观察组和对照组各110例。2组患者均给予利尿脱水降颅压、神经营养等对症治疗,观察组于患者脑出血6h内行微创碎吸手术治疗,而对照组患者手术开始为脑出血后6~24h内行微创碎吸手术治疗。检测2组患者治疗前后血清IL-6和TNF-α水平,并观察2组患者治疗效果和生活质量水平差异。结果治疗前观察组患者血清IL-6与TNF-α水平与对照组相近,差异均无统计学意义(P>0.05)。治疗后,2组患者血清IL-6及TNF-α水平均降低,但观察组患者降低幅度大于对照组,差异均有统计学意义(P<0.05)。观察组患者治疗有效率91.82%显著高于对照组的70.91%,差异有统计学意义(P<0.05)。观察组患者生活质量评价各项指标均高于对照组,差异均有统计学意义(P<0.05)。结论早期微创碎吸术手术治疗高血压脑出血可显著降低患者预后血清IL-6、TNF-α水平,提高治疗有效率和生活质量。
Objective To observe the effect of minimally invasive aspiration surgery on the levels of serum interleukin (IL-6), tumor necrosis factor-α (TNF-α) and quality of life in patients with hypertensive intracerebral hemorrhage. Methods 220 patients with hypertensive cerebral hemorrhage were randomly divided into observation group and control group of 110 cases. 2 patients were given diuretic dehydration reduce intracranial pressure, neurotrophic and other symptomatic treatment, the observation group in patients with intracerebral hemorrhage within 6h minimally invasive surgery, while the control group of patients with cerebral hemorrhage began within 6 ~ 24h after minimally invasive crushing Surgical treatment. The levels of serum IL-6 and TNF-α in two groups were detected before and after treatment, and the differences of therapeutic effect and quality of life between two groups were observed. Results Before treatment, the levels of serum IL-6 and TNF-α in the observation group were similar to those in the control group, with no significant difference (P> 0.05). After treatment, the levels of serum IL-6 and TNF-α decreased in both groups, but the reduction in observation group was larger than that in control group (P <0.05). The effective rate of treatment in observation group was 91.82%, which was significantly higher than that in control group (70.91%), the difference was statistically significant (P <0.05). The indicators of quality of life in observation group were higher than those in control group, the differences were statistically significant (P <0.05). Conclusion Early minimally invasive surgical treatment of hypertensive intracerebral hemorrhage can significantly reduce the prognosis of patients with serum IL-6, TNF-α levels, improve the treatment efficiency and quality of life.